Beta-lactam antibiotics and sulfonamides may be mentioned as an example. There are many antibiotics used in cases of bacteremia by Gram-negative agents.
Characteristics such as age, general state of health of the person before suffering from the infection, environmental conditions in which they live, genetic characteristics and clinical history are factors that were undervalued until a few years ago, but scientific studies have shown that they are very important when deciding on the course of treatment. In order to achieve an effective treatment of sepsis caused by Gram-negative bacteria, two important factors must be considered: the microorganism or microorganisms, in the case there are several, which are responsible for the infection and the patient's physical condition.
For the clinical diagnosis of sepsis, blood culture and sensitivity tests are used, which make the treatment suitable for the agent causing the disease. And if we compare them to those available just two centuries ago, we can say that there are many alternatives for the treatment of patients that suffer from sepsis. The process of inflammatory immune response that occurs when a pathogen passes onto the blood plasma, leading to organ dysfunction, is known as sepsis.1a Sepsis remains to be one of the major causes of mortality in the population, though currently scientists have developed more potent and specific antimicrobial agents than those that existed a few decades ago. The highest concentration of bacterial endotoxins during sepsis treatment is due to bacterial lysis caused by antibiotics, which causes the lipopolysaccharides (LPS) that constitute the cell wall of bacteria to be released into the environment.ĭiscover and quote online our Endotoxin-Specific LAL Reagents HERE When sepsis is caused by Gram-negative bacteria, antibiotic therapies have the disadvantage of producing an increase in the bacterial endotoxin levels in the blood plasma of patients.
The most common treatment for sepsis caused by bacteria, whether Gram-positive or Gram-negative, is the use of antibiotics.
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